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In addition, animal, observational, and genetic studies suggest benefits of GLP-1RAs in people with alcohol use disorder, although randomized trials have produced mixed results, with ongoing trials assessing their effectiveness in those with substance use disorders (SUDs) and mental illnesses

Hair thinning has been noted in association with retatrutide, likely related to rapid weight loss triggering telogen effluvium, though a direct pharmacological effect cannot be excluded as alopecia is listed as an adverse reaction with some licensed GLP-1 receptor agonists